简 历:
2021年9月—至今:中科院计算所,研究员
2016年9月—2021年9月,中科院计算所,副研究员
2013年7月—2016年9月,中科院计算所,助理研究员
2006年9月—2013年7月,中国科学院大学,计算机学院,工学博士
2002年9月—2006年7月,吉林大学,计算机科学与技术学院,本科生
主要论著:
期刊文章:
1.Zhang, X.; Cheng, K.; Ning, Z.; Mayne, J.; Walker, K.; Chi, H.; Farnsworth, C. L.; Lee, K.; Figeys, D., Exploring the Microbiome-Wide Lysine Acetylation, Succinylation, and Propionylation in Human Gut Microbiota. ANALYTICAL CHEMISTRY 2021, 93 (17), 6594-6598.
2.Chen, Z.-L.; Mao, P.-Z.; Zeng, W.-F.; Chi, H.; He, S.-M., pDeepXL: MS/MS Spectrum Prediction for Cross-Linked Peptide Pairs by Deep Learning. JOURNAL OF PROTEOME RESEARCH 2021, 20 (5), 2570-2582.
3.Shao, G.-C; Cao, Y; Chen, Z.-L.; Liu, C; Li, S.-T.; Chi, H.; Dong, M.-Q., How to use open-pFind in deep proteomics data analysis?-A protocol for rigorous identification and quantitation of peptides and proteins from mass spectrometry data. Biophysics Reports 2021, 7 (3), 207-226.
4.Wu, S.; Sun, J.; Wang, X.; Xu, F.; Chi, H.; Li, Y.; Zhong, B.; Xie, Y.; Yan, Z.; Chang, L.; Wang, D.; He, F.; Wu, J.; Zhang, Y.; Xu, P., Open-pFind Verified Four Missing Proteins from Multi-Tissues. JOURNAL OF PROTEOME RESEARCH 2020, 19 (12), 4808-4814.
5.Fei, Z.; Wang, K.; Chi, H., GameTag: A New Sequence Tag Generation Algorithm Based on Cooperative Game Theory. PROTEOMICS 2020, 20 (21-22).
6.Zhou, W.-J.; Yang, H.; Zeng, W.-F.; Zhang, K.; Chi, H.; He, S.-M., pValid: Validation Beyond the Target-Decoy Approach for Peptide Identification in Shotgun Proteomics. JOURNAL OF PROTEOME RESEARCH 2019, 18 (7), 2747-2758.
7.Zhang, S.; Cao, X.; Liu, C.; Li, W.; Zeng, W.; Li, B.; Chi, H.; Liu, M.; Qin, X.; Tang, L.; Yan, G.; Ge, Z.; Liu, Y.; Gao, Q.; Lu, H., N-glycopeptide Signatures of IgA2 in Serum from Patients with Hepatitis B Virus-related Liver Diseases. Molecular & cellular proteomics : MCP 2019, 18 (11), 2262-2272.
8.Yang, H.; Li, Y.-C.; Zhao, M.-Z.; Wu, F.-L.; Wang, X.; Xiao, W.-D.; Wang, Y.-H.; Zhang, J.-L.; Wang, F.-Q.; Xu, F.; Zeng, W.-F.; Overall, C. M.; He, S.-M.; Chi, H.; Xu, P., Precision De Novo Peptide Sequencing Using Mirror Proteases of Ac-LysargiNase and Trypsin for Large-scale Proteomics. Molecular & cellular proteomics : MCP 2019, 18 (4), 773-785.
9.Yang, H.; Chi, H.; Zeng, W.-F.; Zhou, W.-J.; He, S.-M., pNovo 3: precise de novo peptide sequencing using a learning-to-rank framework. BIOINFORMATICS 2019, 35 (14), I183-I190.
10.Li, W.; Chi, H.; Salovska, B.; Wu, C.; Sun, L.; Rosenberger, G.; Liu, Y., Assessing the Relationship Between Mass Window Width and Retention Time Scheduling on Protein Coverage for Data-Independent Acquisition. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2019, 30 (8), 1396-1405.
11.Chen, Z.-L.; Meng, J.-M.; Cao, Y.; Yin, J.-L.; Fang, R.-Q.; Fan, S.-B.; Liu, C.; Zeng, W.-F.; Ding, Y.-H.; Tan, D.; Wu, L.; Zhou, W.-J.; Chi, H.; Sun, R.-X.; Dong, M.-Q.; He, S.-M., A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides. NATURE COMMUNICATIONS 2019, 10.
12.Yang, H.; Chi, H.; Zhou, W.-J.; Zeng, W.-F.; Liu, C.; Wang, R.-M.; Wang, Z.-W.; Niu, X.-N.; Chen, Z.-L.; He, S.-M., pSite: Amino Acid Confidence Evaluation for Quality Control of De Novo Peptide Sequencing and Modification Site Localization. JOURNAL OF PROTEOME RESEARCH 2018, 17 (1), 119-128.
13.Chi, H.; Liu, C.; Yang, H.; Zeng, W.-F.; Wu, L.; Zhou, W.-J.; Wang, R.-M.; Niu, X.-N.; Ding, Y.-H.; Zhang, Y.; Wang, Z.-W.; Chen, Z.-L.; Sun, R.-X.; Liu, T.; Tan, G.-M.; Dong, M.-Q.; Xu, P.; Zhang, P.-H.; He, S.-M., Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine. NATURE BIOTECHNOLOGY 2018, 36 (11), 1059-+.
14.Zhou, X.-X.; Zeng, W.-F.; Chi, H.; Luo, C.; Liu, C.; Zhan, J.; He, S.-M.; Zhang, Z., pDeep: Predicting MS/MS Spectra of Peptides with Deep Learning. ANALYTICAL CHEMISTRY 2017, 89 (23), 12690-12697.
15.Yang, H.; Chi, H.; Zhou, W.-J.; Zeng, W.-F.; He, K.; Liu, C.; Sun, R.-X.; He, S.-M., Open-pNovo: De Novo Peptide Sequencing with Thousands of Protein Modifications. JOURNAL OF PROTEOME RESEARCH 2017, 16 (2), 645-654.
16.Liu, M.-Q.; Zeng, W.-F.; Fang, P.; Cao, W.-Q.; Liu, C.; Yan, G.-Q.; Zhang, Y.; Peng, C.; Wu, J.-Q.; Zhang, X.-J.; Tu, H.-J.; Chi, H.; Sun, R.-X.; Cao, Y.; Dong, M.-Q.; Jiang, B.-Y.; Huang, J.-M.; Shen, H.-L.; Wong, C. C. L.; He, S.-M.; Yang, P.-Y., pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification. NATURE COMMUNICATIONS 2017, 8.
17.Bu, S.-L.; Liu, C.; Liu, N.; Zhao, J.-L.; Ai, L.-F.; Chi, H.; Li, K. L.; Chien, C.-W.; Burlingame, A. L.; Zhang, S.-W.; Wang, Z.-Y., Immunopurification and Mass Spectrometry Identifies Protein Phosphatase 2A (PP2A) and BIN2/GSK3 as Regulators of AKS Transcription Factors in Arabidopsis. MOLECULAR PLANT 2017, 10 (2), 345-348.
18.Zeng, W.-F.; Liu, M.-Q.; Zhang, Y.; Wu, J.-Q.; Fang, P.; Peng, C.; Nie, A.; Yan, G.; Cao, W.; Liu, C.; Chi, H.; Sun, R.-X.; Wong, C. C. L.; He, S.-M.; Yang, P., pGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD-and CID-MS/MS and MS3. SCIENTIFIC REPORTS 2016, 6.
19.Sun, R.-X.; Luo, L.; Wu, L.; Wang, R.-M.; Zeng, W.-F.; Chi, H.; Liu, C.; He, S.-M., pTop 1.0: A High-Accuracy and High-Efficiency Search Engine for Intact Protein Identification. ANALYTICAL CHEMISTRY 2016, 88 (6), 3082-3090.
20.Zhang, K.; Fu, Y.; Zeng, W.-F.; He, K.; Chi, H.; Liu, C.; Li, Y.-C.; Gao, Y.; Xu, P.; He, S.-M., A note on the false discovery rate of novel peptides in proteogenomics. BIOINFORMATICS 2015, 31 (20), 3249-3253.
21.Sun, R.-X.; Luo, L.; Chi, H.; Liu, C.; He, S.-M., Top-down Proteomics: The Large-scale Proteoform Identification. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 2015, 42 (2), 101-114.
22.Fan, S.-B.; Meng, J.-M.; Lu, S.; Zhang, K.; Yang, H.; Chi, H.; Sun, R.-X.; Dong, M.-Q.; He, S.-M., Using pLink to Analyze Cross-Linked Peptides. Current protocols in bioinformatics 2015, 49, 8.21.1-8.21.19.
23.Chi, H.; He, K.; Yang, B.; Chen, Z.; Sun, R.-X.; Fan, S.-B.; Zhang, K.; Liu, C.; Yuan, Z.-F.; Wang, Q.-H.; Liu, S.-Q.; Dong, M.-Q.; He, S.-M., pFind-Alioth: A novel unrestricted database search algorithm to improve the interpretation of high-resolution MS/MS data (Reprinted from vol 125, pg 89-97, 2015). JOURNAL OF PROTEOMICS 2015, 129, 33-41.
24.Su, Z.-D.; Sheng, Q.-H.; Li, Q.-R.; Chi, H.; Jiang, X.; Yan, Z.; Fu, N.; He, S.-M.; Khaitovich, P.; Wu, J.-R.; Zeng, R., De novo identification and quantification of single amino-acid variants in human brain. JOURNAL OF MOLECULAR CELL BIOLOGY 2014, 6 (5), 421-433.
25.Liu, C.; Song, C.-Q.; Yuan, Z.-F.; Fu, Y.; Chi, H.; Wang, L.-H.; Fan, S.-B.; Zhang, K.; Zeng, W.-F.; He, S.-M.; Dong, M.-Q.; Sun, R.-X., pQuant Improves Quantitation by Keeping out Interfering Signals and Evaluating the Accuracy of Calculated Ratios. ANALYTICAL CHEMISTRY 2014, 86 (11), 5286-5294.
26.Fan, S.-B.; Wu, Y.-J.; Yang, B.; Chi, H.; Meng, J.-M.; Lu, S.; Zhang, K.; Wu, L.; Sun, R.-X.; Dong, M.-Q.; He, S.-M., A New Approach to Protein Structure and Interaction Research: Chemical Cross-linking in Combination With Mass Spectrometry. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 2014, 41 (11), 1109-1125.
27.Zhang, K.; Wang, L.-H.; Chi, H.; Bu, D.-C.; Yuan, Z.-F.; Liu, C.; Fan, S.-B.; Chen, H.-F.; Zeng, W.-F.; Luo, H.-T.; Sun, R.-X.; He, S.-M.; Xie, L.; Zhao, Y., Proteogenomics: Improving Genomes Annotation by Proteomics. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 2013, 40 (4), 297-308.
28.Yuan, Z.-F.; Wu, L.; Liu, C.; Chi, H.; Fan, S.-B.; Zhang, K.; Zeng, W.-F.; Sun, R.-X.; He, S.-M., Accurate Determination of Precursor Ions for Peptides in Large-scale Protein Identification. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 2013, 40 (1), 80-92.
29.Chi, H.; Chen, H.; He, K.; Wu, L.; Yang, B.; Sun, R.-X.; Liu, J.; Zeng, W.-F.; Song, C.-Q.; He, S.-M.; Dong, M.-Q., pNovo+: De Novo Peptide Sequencing Using Complementary HCD and ETD Tandem Mass Spectra. JOURNAL OF PROTEOME RESEARCH 2013, 12 (2), 615-625.
30.Yuan, Z.-F.; Liu, C.; Wang, H.-P.; Sun, R.-X.; Fu, Y.; Zhang, J.-F.; Wang, L.-H.; Chi, H.; Li, Y.; Xiu, L.-Y.; Wang, W.-P.; He, S.-M., pParse: A method for accurate determination of monoisotopic peaks in high-resolution mass spectra. PROTEOMICS 2012, 12 (2), 226-235.
31.Ye, D.; Fu, Y.; Sun, R.-X.; Wang, H.-P.; Yuan, Z.-F.; Chi, H.; He, S.-M., Open MS/MS spectral library search to identify unanticipated post-translational modifications and increase spectral identification rate. BIOINFORMATICS 2010, 26 (12), i399-i406.
32.Sun, R.-X.; Dong, M.-Q.; Song, C.-Q.; Chi, H.; Yang, B.; Xiu, L.-Y.; Tao, L.; Jing, Z.-Y.; Liu, C.; Wang, L.-H.; Fu, Y.; He, S.-M., Improved Peptide Identification for Proteomic Analysis Based on Comprehensive Characterization of Electron Transfer Dissociation Spectra. JOURNAL OF PROTEOME RESEARCH 2010, 9 (12), 6354-6367.
33.Liu, C.; Wang, H.; Fu, Y.; Yuan, Z.; Chi, H.; Wang, L.; Sun, R.; He, S., [Prediction of peptide retention time in reversed-phase liquid chromatography and its application in protein identification]. Se pu = Chinese journal of chromatography 2010, 28 (6), 529-34.
34.Li, Y.; Chi, H.; Wang, L.-H.; Wang, H.-P.; Fu, Y.; Yuan, Z.-F.; Li, S.-J.; Liu, Y.-S.; Sun, R.-X.; Zeng, R.; He, S.-M., Speeding up tandem mass spectrometry based database searching by peptide and spectrum indexing. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 2010, 24 (6), 807-814.
35.Chi, H.; Sun, R.-X.; Yang, B.; Song, C.-Q.; Wang, L.-H.; Liu, C.; Fu, Y.; Yuan, Z.-F.; Wang, H.-P.; He, S.-M.; Dong, M.-Q., pNovo: De novo Peptide Sequencing and Identification Using HCD Spectra. JOURNAL OF PROTEOME RESEARCH 2010, 9 (5), 2713-2724.
36.Fu, Y.; Jia, W.; Lu, Z.; Wang, H.; Yuan, Z.; Chi, H.; Li, Y.; Xiu, L.; Wang, W.; Liu, C.; Wang, L.; Sun, R.; Gao, W.; Qian, X.; He, S.-M., Efficient discovery of abundant post-translational modifications and spectral pairs using peptide mass and retention time differences. BMC BIOINFORMATICS 2009, 10.
科研项目:
[1] 国家自然科学基金优秀青年科学基金:计算蛋白质组学,课题负责人,2021.01-2023.12
[2] 国家自然科学基金面上项目:新一代从头测序算法设计与应用研究,课题负责人,2015.01-2018.12
获奖及荣誉:
2021:中国人类蛋白质组组织(CNHUPO)学术振兴奖
2019:中国计算机学会技术发明一等奖,第二完成人
2018:中国生物信息学十大进展
2018:中国科学院计算技术研究所“卓越之星”
2013:中国科学院院长特别奖
2010:中国科学院计算技术研究所优秀论文一等奖
迟浩 研究员
研究方向:
所属部门:前瞻研究实验室
导师类别:博导, 计算机应用技术
联系方式:chihao@ict.ac.cn
个人网页:http://pfind.org/people/chihao/index.htm